Tumorigenicity of the miR-17-92 cluster distilled

miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity

Downlo ammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, ing apoptosis and senescence, which are compromised by additional mutations before cancers are develThe miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed an cancers and has been shown to promote several aspects of oncogenic transformation, ...

The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence.

In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed. The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic t...

New Insights Into miR-17-92 Cluster Regulation and Angiogenesis.

MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer

The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous CRC has not been elucidated. In the present study, the expression profile of miRNA and snoRNA in 5 syn...

[Characterization of the structure, function and regulation of the chicken mir-17-92 cluster].

The miRNA cluster mir-17-92 is conserved in vertebrates and plays crucial roles in cell proliferation, differentiation, apoptosis and animal development. The mir-17-92 cluster also acts as an oncogene that is expressed in variety of cancers. Despite extensive study, the molecular mechanism underlying its functions is not fully understood. The fact that miRNAs in the same cluster are functionall...